We’re in the home stretch of the 2021 season with just three weeks remaining. Week 16 promises to paint an even clearer picture of who’s for real and who’s not as the playoff standings really take shape. Of course, you’re here to get an inside track of who has the best shot at coming out on top in Week 16 to keep you betting sharp. And you’ve come to the right place.
Each week, we collect all of the best picks and gambling content from CBSSports.com and SportsLine in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more.
All NFL odds via Caesars Sportsbook.
Which NFL picks can you make with confidence. And which Super Bowl contender will go down hard? Visit SportsLine now to see which teams win and cover the spread, all from a proven computer model on a 133-96 roll on NFL picks.
Browns at Packers
Time: Saturday, 4 p.m. ET (Fox, NFL Network), stream on fuboTV (try for free)Open: Packers -7Current: Packers -7.5
“Cleveland is in a tough spot. The Browns are coming off the heels of feeling the wrath of COVID-19, which moved their Week 15 game from Saturday to Monday, and will now have to prepare for Aaron Rodgers and the red-hot Packers on an extremely short week. Green Bay is playing as good as any team in the NFL right now and has been a superb team to back all season, owning an 11-3 ATS record (tied for the best in the NFL). When the Packers own the rest advantage, they are 2-0 ATS this season. Meanwhile, Cleveland is under .500 on the year ATS and 1-4 ATS in its last five games overall.” — CBS Sports’ Tyler Sullivan on why he likes the Packers to win by more than a touchdown in Week 16.
Sullivan, who’s gone 44-27-4 this season on ATS Locks of the Week, has picks for a bunch of other key Week 16 games as well. Check out his picks right here.
Colts at Cardinals
Time: Saturday, 8:15 p.m. ET (NFL Network), stream on fuboTV (try for free)Open: Cardinals -1.5Current: Cardinals -1
“The Colts are a bully. They beat you up at the point of attack on both sides of the ball, and lately the Cardinals look like a team that is questioning its own identity and questioning its own record. … I know Arizona’s at home, but I like the Colts’ ability to run the ball down their throat, and they proved last week they can beat a quality opponent with Carson Wentz doing next to nothing. …These seem to be two teams going in different directions.” — CBS Sports NFL insider Jason La Canfora on why he’s betting on the road underdogs in this matchup of contenders.
La Canfora, who went 12-4 making ATS picks in Week 15, has other best bets specifically for this week’s slate. Check them out right here at CBS Sports.
Giants at Eagles
Time: Sunday, 1 p.m. ET (Fox), stream on fuboTV (try for free)Open: Eagles -10Current: Eagles -10
“Jake Fromm may be making his first-career start. There’s a chance he actually injects some energy into this team, but there’s also a chance he flops. As for the Eagles, they are pumped up after their 10-point win over Washington. They have a legitimate chance at the playoffs, and will want to destroy a lesser division rival that beat them in a gross game with Daniel Jones last month.” — CBS Sports’ Jordan Dajani on why he’s backing the Eagles over their NFC East rivals in Week 16’s important rematch.
Dajani also has picks for other key games on the Week 16 slate. Check all of them out right here.
Jaguars at Jets
Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+ (click here)Open: Jets -1.5Current: Jets -1.5
“The Jaguars defense has played well, don’t get me wrong. (But) as bad as the Jets are on offense, the Jaguars are worse. They’re terrible on offense. They have nobody who can scare downfield (and) … Trevor Lawrence is starting to regress. His mechanics are terrible. I’ll take the Jets.” — CBS Sports senior writer and resident Jaguars expert Pete Prisco on why the Jets deserve to be favored in this matchup of lowly AFC teams.
Catch the rest of Prisco’s analysis, plus picks for every single Week 16 showdown, on the “Pick Six NFL Podcast” (subscribe and listen below):
Lions at Falcons
Time: Sunday, 1 p.m. ET (Fox), stream on fuboTV (try for free)Open: Falcons -6.5Current: Falcons -6.5
“The Lions beat the Vikings, 29-27. And the next week they went out and got absolutely smoked by the Broncos, 38-10. They take care of business against the Cardinals, get to 2-11-1. They should be thrilled that they got the two wins. …Atlanta has a penchant for beating up on bad football teams, then getting crushed by good football teams. The Falcons are not good, but they’re better than really, really bad. And they will beat the Lions handily in this spot.” — CBS Sports’ Will Brinson explaining why he’s all over Atlanta on the “Pick Six NFL Podcast” ahead of Week 16.
Check out Brinson’s full explanation, as well as projections for every single Week 16 matchup, on the latest “Pick Six NFL Podcast.”
Bills at Patriots
Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+ (click here)Open: Patriots -2Current: Patriots -2.5
“The Patriots were a clear play here before the prime-time windfest, but the Bills’ COVID issues could shoot this line up over three, which is a little concerning if you get the full Bills offense. Buffalo scares the hell out of me right now — Sean McDermott’s been on tilt for three or four weeks since the wind game, a crazy comeback against the Bucs where he was crying at halftime and then playing his old team. He might just be crazy enough to pull off an upset … but (Bill) Belichick after a loss weighs substantially more on this game. Factor in the Bills’ inability to stop the run, how Belichick can attack this offense with a double of Stefon Diggs, and the COVID situation, and I think the Pats are a great value here.” — CBS Sports senior writer Will Brinson on why the Patriots are probably a safe bet to handily beat the Bills in this AFC East rematch.
Brinson, who went 9-5 ATS in Week 15, has projections for every single Week 16 matchup. Get them all right here.
Buccaneers at Panthers
Time: Sunday, 1 p.m. ET (Fox), stream on fuboTV (try for free)Open: Buccaneers -11.5Current: Buccaneers -10
SportsLine’s Mike Tierney is all over teasers this season. If you’re unfamiliar, a teaser is a play that involves at least two games with more favorable point spreads than are offered with a traditional bet. Our picks will be limited to two-game, six-point teasers, meaning that a half-dozen points will be tacked on in favor of our chosen team in each game.
We can tell you he likes teasing Buccaneers-Panthers to Under 50. Head on over to SportsLine to see what else he’s betting on this week.
Chargers at Texans
Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+ (click here)Open: Chargers -10.5Current: Chargers -9.5
“The Texans are terrible, and the Chargers offense is playing extremely well. Los Angeles already ranks third in the league in points per drive at 2.57, but over the last five games, that number is at 2.83. Now, on the flip side, the Chargers defense has been bad most of the season, but Houston’s offense is terrible, too. While I don’t think the Chargers can truly blow the doors off anybody with their defense, I do think they can score enough to cover this spread against a Texans team with nothing to play for. ” — CBS Sports’ Tom Fornelli, explaining why he’s comfortable betting on L.A. to win and cover the big spread against Houston in Week 16.
Fornelli, who is 25-17 this season on top ATS bets, also has projections for a couple of other key lines in Week 16. Check out his full analysis right here.
Ravens at Bengals
Time: Sunday, 1 p.m. ET (CBS), stream on Paramount+ (click here)Open: Bengals -2.5Current: Bengals -3.5
“If this turns into a shootout, you have to like the Bengals’ chances going up against a depleted Baltimore defense. … (The) Ravens offense will (also) either be led by a hobbled Lamar Jackson or a backup quarterback (Tyler Huntley) while going up against a Bengals defense that held them to just 17 points the last time around. … Although the Bengals have a long history of choking in big games, they’ve actually won a multitude of them this season, which is a good thing, because this is easily the biggest game the Bengals have hosted at home since at least the 2015 season. … I don’t think they’re going to blow this one.” — CBS Sports writer and resident Bengals expert John Breech, arguing that Cincinnati is a trustworthy bet in its rematch with the Ravens.
Breech, who went 10-5-1 in ATS picks in Week 15 and has gone 140-83-1 in straight-up picks this year, has picks for every single Week 16 matchup at CBS Sports. Check them out right here.
Rams at Vikings
Time: Sunday, 1 p.m. ET (Fox), stream on fuboTV (try for free) Open: Rams -3Current: Rams -3
“This is a bigger game for the Vikings if they are to have any chance to be a playoff team. The Rams are coming off a nice victory over Seattle that saw the defense play well. But the offense wasn’t as crisp. It will be here. But Minnesota will also play well on offense. Look for a lot of points with the Vikings pulling off a home upset.” — CBS Sports senior writer Pete Prisco on why he’s not buying the Rams as field-goal favorites in Minnesota.
Prisco, who went 11-5 in ATS picks in Week 15 and has gone 137-86-1 in straight-up predictions this season, also made picks for every other Week 16 matchup. Check out his analysis right here.
Bears at Seahawks
Time: Sunday, 4:05 p.m. ET (Fox), stream on fuboTV (try for free) Open: Seahawks -7Current: Seahawks -6.5
The Seahawks are playing for pride now, having dropped a key divisional game against the Rams in Week 15. But their opponent this week is even more resigned to restarting in 2022: the Bears were as uninspiring as ever — at least with the ball in their hands — during their loss to Minnesota, dropping Matt Nagy’s squad to 4-10 on the year. We’d still count on Russell Wilson and Pete Carroll over Nagy and third-string QB Nick Foles in this NFC matchup.
The SportsLine projection model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception more than six years ago. We can tell you the model wisely leans Seahawks as a survivor pick in Week 16, but you’ll wanna check out SportsLine for a full rundown of best bets this weekend.
Broncos at Raiders
Time: Sunday, 4:25 p.m. ET (CBS), stream on Paramount+ (click here)Open: Broncos -1Current: PK
“Look, I certainly believe Teddy Bridgewater is a better quarterback than Drew Lock, but it’s not like the passing game has been lighting up the scoreboard over the last two months. The Broncos’ high-water mark for net passing yards since Week 6 is just 250 yards, and that came in the 22-9 loss to the Chiefs in a game more competitive than the final score indicates. But the Broncos have played mostly quality football by excelling at running the ball and playing defense, and that’s a formula I expect works in this matchup.” — SportsLine expert and CBS Sports fantasy and gambling editor R.J. White in his SuperContest picks for Week 16.
R.J. has cashed twice in the Westgate SuperContest, widely considered the toughest sports gambling competition in the world. He’s also hit on over 57% of his picks over the past six years combined. You can see all five of his Week 16 picks against the SuperContest lines and the Circa Sports Million lines by heading over to SportsLine.
Washington at Dallas
Time: Sunday, 8:20 p.m. ET (NBC), stream on fuboTV (try for free)Open: Cowboys -9Current: Cowboys -10
The Cowboys are on a three-game winning streak atop the NFC East, and technically still in play for the conference’s No. 1 seed. But they’ll get a desperate Washington team in prime time this week, after the Football Team fell to 6-8 thanks to a rash of COVID issues and a divisional loss to the Eagles. Does Washington have what it takes to rebound in a big spot? You’d be wise to listen to SportsLine expert Mike Tierney, who’s an astounding 27-12-1 in his last 40 ATS picks involving Washington.
Does Tierney believe the Cowboys are right to be favored by more than 10 points on “Sunday Night Football”? We can tell you he’s leaning Over, but you’ll wanna head over to SportsLine to get his full ATS projection on the matchup.
Dolphins at Saints
Time: Monday, 8:15 p.m. ET (ESPN), stream on fuboTV (try for free)Open: Saints -3.5Current: Saints +2.5
The Dolphins have won six straight, threatening to sneak their way right back into the AFC playoff picture. But are they a safe bet to make it seven straight against the Saints, who just shut out the reigning Super Bowl champions? You’d be hard-pressed to find anyone with a better pulse for New Orleans lately than Larry Hartstein, who’s turned nearly a $2,500 profit with a 61-32 record in his last 93 NFL picks. He’s also 39-24 on his last 63 ATS picks involving the Saints.
Does Hartstein think the Dolphins’ win streak will come to a close in New Orleans? We can tell you he’s leaning Under for the total, but you’ll wanna check out his full ATS projection on SportsLine.