LSU vs. Mississippi State odds, line, spread: 2021 college football picks, predictions from model on 72-58 run


Ed Orgeron and the LSU Tigers hit the road to open conference play on Saturday. LSU is 2-1 this season in nonconference play, but the Tigers face an SEC West challenge against Mike Leach and Mississippi State this weekend. The Bulldogs are also 2-1, winning their first two games before a road loss in Memphis. Mississippi State is also opening its conference slate.

Kickoff is set for noon ET. The latest LSU vs. Mississippi State odds from Caesars Sportsbook list the Tigers as 2.5-point favorites , while the over-under for total points is set at 56.5. Before locking in any Mississippi State vs. LSU picks, make sure you see the college football predictions and betting advice from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on LSU vs. Mississippi State. You can visit SportsLine now to see the picks. Here are the college football odds and trends for Mississippi State vs. LSU:

LSU vs. Mississippi State spread: LSU -2.5LSU vs. Mississippi State over-under: 56.5 pointsLSU vs. Mississippi State money line: LSU -135, MSU +115LSU: The Tigers are 7-6 against the spread in the last 13 gamesMSU: The Bulldogs are 6-8 against the spread in the last 14 games

Featured Game | Mississippi State Bulldogs vs. LSU Tigers

Why LSU can cover

The Tigers have been strong defensively this season, particularly in response to a shakier effort against UCLA to open the season. LSU is allowing fewer than 300 total yards per game, and the Tigers are giving up only 110 yards per game on the ground. That includes the Tigers limiting opponents to only 2.8 yards per carry for the season. Against the pass, LSU is also playing well, including a 58.7 percent completion rate allowed, and the Tigers are creating havoc with regularity. The defense has 17 sacks, comfortably leading the SEC, and there are individual standouts to lean on all over the defense. 

Senior linebacker Damone Clark leads the SEC in solo tackles, with 19 stops on his own. Up front, sophomore defensive end BJ Ojulari leads the conference with 4.5 sacks in only three games. On the backend, junior cornerback Derek Stingley Jr. is questionable with a foot injury, but there is elite talent all over the place. LSU will have its hands full against Mississippi State’s passing attack, but the Tigers are fully equipped.

Why Mississippi State can cover

Under Leach, the Bulldogs love to attack through the air, and they’ve enjoyed success with it in 2021. Sophomore quarterback Will Rogers currently leads the SEC in passing yards (1,083), completion percentage (74.8) and completions (122), with Mississippi State leading the conference in passing offense. Rogers has a pair of top-flight pass-catchers in receiver Makai Polk and running back Jo’quavious Marks, with Polk and Marks ranking as the top two players in the SEC in receptions. 

In 2020, Mississippi State threw for more than 600 yards against LSU, and that led the team to an upset road win. Defensively, Mississippi State is also quite stout. The Bulldogs are giving up only 3.0 yards per carry and 74 yards per game on the ground. Against the pass, the Bulldogs have four interceptions, with opponents completing only 57.8 percent of their passes and averaging a meager 6.3 yards per pass attempt for only five touchdowns in three games.

How to make Mississippi State vs. LSU picks

SportsLine’s model is leaning over on the total, projecting 60 combined points. The model also says one side of the spread hits in almost 60 percent of simulations. You can only get the pick at SportsLine. 

So who wins LSU vs. Mississippi State? And which side of the spread hits in almost 60 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.  



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