College football odds, lines, picks, bets, predictions for Week 4, 2021: Proven model backing LSU, UCLA


The Week 4 college football schedule features two ranked vs. ranked matchups, and neither takes place in a college stadium. No. 7 Texas A&M vs. No. 16 Arkansas is at AT&T Stadium in Dallas and No. 12 Notre Dame vs. No. 18 Wisconsin is at Soldier Field in Chicago. The latest Week 4 college football odds at Caesars Sportsbook list A&M and Wisconsin as 5.5-point favorites.

No. 10 Ohio State is the biggest favorite of the week in the Week 4 college football lines at Caesars, coming in at -49 against Akron, with No. 1 Alabama not far behind as a 45-point favorite against Southern Miss. Elsewhere, No. 4 Oklahoma is -16.5 against West Virginia, No. 2 Georgia is -34.5 vs. Vanderbilt and No. 3 Oregon is -28.5 vs. Arizona. Before making any Week 4 college football picks on those games or others, be sure to see the latest college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 4 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 4 college football predictions

One of the top college football picks the model is recommending for Week 4: LSU covers -2.5 vs. Mississippi State. The Tigers have underwhelmed so far in 2021, losing to UCLA to open the season. But they took care of business against McNeese State and Central Michigan, so this week is almost a restart to their season.

The model predicts a big day for Max Johnson, who stepped into the starting quarterback role for LSU once again after Myles Brennan went down with an injury before the season. And after MSU lit up the Tigers to open last season, look for new coordinator Daronte Jones to not make the same mistakes his predecessor did. LSU wins and covers in almost 60 percent of simulations of this game, per SportsLine, and the point total goes over 56 in more than 50 percent of simulations.

Another one of the college football predictions from the model: No. 24 UCLA (-6) covers on the road against Stanford at 6 p.m. ET on Saturday. Unlike the SEC, there is room for new teams to make a move to the top of the Pac-12 this season. UCLA has positioned itself to challenge for one of those spots, and the Bruins have a great chance to push forward this week against the Cardinal.

Even in a close loss last weekend to Fresno State, UCLA quarterback Dorian Thompson-Robinson threw for 278 yards, three touchdowns and zero interceptions. Bruins running back Zach Charbonnet has a 10.5-yard per carry average and Stanford’s defense surrenders more than 210 rushing yards per game. That sort of offensive output supports why the model’s simulations show UCLA covering the spread 60 percent of the time. 

How to make Week 4 college football picks 

The model has also made the call on who wins and covers in every other game on the Week 4 college football schedule, and it’s calling for a Top 25 favorite to go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which Top 25 favorite goes down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past five-plus seasons, and find out.

Week 4 college football odds (via Caesars)

Here are the college football lines for some of Week 4’s most notable matchups:

Thursday, Sept. 23

Marshall vs. Appalachian State (-7.5, 57)

Featured Game | Appalachian State Mountaineers vs. Marshall Thundering Herd

Friday, Sept. 24

MTSU vs. Charlotte (-2.5, 56.5)

Featured Game | Charlotte 49ers vs. Middle Tenn. Blue Raiders

Wake Forest vs. Virginia (-4, 67)

Featured Game | Virginia Cavaliers vs. Wake Forest Demon Deacons

Liberty vs. Syracuse (+6, 52.5)

Featured Game | Syracuse Orange vs. Liberty Flames

Fresno State vs. UNLV (+31.5, 58.5)

Featured Game | Fresno State Bulldogs vs. UNLV Rebels

Saturday, Sept. 25

Georgia vs. Vanderbilt (+34, 51)

Notre Dame vs. Wisconsin (-5.5, 46.5)

Featured Game | Wisconsin Badgers vs. Notre Dame Fighting Irish

UMass vs. Coastal Carolina (-36, 67)

Rutgers vs. Michigan (-18.5, 51.5)

Clemson vs. NC State (+10, 47)

Featured Game | NC State Wolfpack vs. Clemson Tigers

Iowa State vs. Baylor (+6.5, 47.5)

Featured Game | Baylor Bears vs. Iowa State Cyclones

Colorado State vs. Iowa (-23, 44.5)

Featured Game | Iowa Hawkeyes vs. Colorado State Rams

Texas A&M vs. Arkansas (+5.5, 48)

Featured Game | Arkansas Razorbacks vs. Texas A&M Aggies

Georgia State vs. Auburn (-27, 57)

Featured Game | Arkansas Razorbacks vs. Texas A&M Aggies

UCLA vs. Stanford (+6, 58.5)

Featured Game | Stanford Cardinal vs. UCLA Bruins

Nebraska vs. Michigan State (-5, 51.5)

Featured Game | Michigan State Spartans vs. Nebraska Cornhuskers

Kansas State vs. Oklahoma State (-6, 45)

Featured Game | Oklahoma State Cowboys vs. Kansas State Wildcats

North Carolina vs. Georgia Tech (+12, 63)

Featured Game | Georgia Tech Yellow Jackets vs. North Carolina Tar Heels

Akron vs. Ohio State (-49, 67.5)

Alabama vs. Southern Mississippi (+45, 57.5)

Oklahoma vs. West Virginia (+16.5, 59)

Featured Game | Oklahoma Sooners vs. West Virginia Mountaineers

USF vs. BYU (-23, 52)

Featured Game | BYU Cougars vs. South Florida Bulls

Arizona vs. Oregon (-28, 58)

Featured Game | Oregon Ducks vs. Arizona Wildcats



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